Part:BBa_K4165246
Clamp [5]
Clamp [5] composed of Seed Binding Peptide Seed (BBa_K4165012) , linker length of GGSGG (BBa_K4165226), Amyloid beta R8 peptide (BBa_K4165180). Our Clamp design was based on our project aim for binding with Tau and amyloid beta for further degradation.
Usage and Biology
According to Previous Research results, Our binding peptides proved to have dual effect of binding to both Tau and amyloid beta . According to this , we designed our clamps consists of various linker lengths and peptides parts for further validation of this theory and analysis by wet-lab and dry lab results. According to our project Criteria , our clamps supposed to have binding affinity for tau and amyloid beta high enough to make the inhibitor (BBa_K4165008) , (BBa_K4165010) unbind from catalytic domain of HTRA1 protease system (BBa_K4165004).
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12INCOMPATIBLE WITH RFC[12]Illegal NotI site found at 32
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
3D Modeling and Ranking
Figure 1. The 3D structure of Clamp [5] modeled by AppTest
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